| Speaker : |
Dr. Wolfgang Fritzsche (Head of Department "Biotechnical Microsystems" Institute for Technology Jena, Germany) |
| Subject : |
Bridging molecular constructs with the macroscopic world: Concepts based on a combination of biomolecular self organization and microsystem technology |
| Date : |
November 9, 2004 (Conference room 1, Institute of Industrial Science, Komaba campus)
November 11,2004 (Lecture room 84, Faculty of Engineering bldg.8, Hongo campus) |
| Abstract : |
Nanoscale devices and materials based on molecular units represent an interesting option for further technical progress. Although such complexes are known from biology and supramolecular chemistry, their use in a technological setting is hampered by a missing incorporation into existing technical systems. This integration problem is only solved for selected systems using rather elaborate approaches. For a broad application, a general solution is needed.
We propose an approach combining microstructured substrates with dedicated binding spots for individual long molecules, where the long molecules present the base for a second level of positioning. In the case of long DNA, this level would be provided by sequence-specific hybridization of complementary short DNA conjugated e.g. to metal nanoparticles or fluorescence dyes. In combination with other
bio-inorganic techniques like DNA metallization or superstructures, we developed a toolbox for molecular constructions with microstructured substrates as connecting part to the technical world, with DNA as tool for self-organization and positioning, and metal nanoparticles as active parts for optical and electronic processes.
I will present first steps in this envisioned development; such as the preparation of DNA-modified nanoparticles and their use in novel DNA chip detection schemes, the preparation of metal nanoparticles of customized optical properties including possible applications, and a highly parallel approach for positioning of individual DNA structures into microstructured electrode arrays prior to selective metallization of the positioned molecular structure. |
|
|
